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DTPA: A One-Stop Heavy Metal Shop

A number of health care practitioners and GDD subjects have asked me about the comparative binding strengths of DTPA compared to other chelating agents for Gd and other heavy metals. This is from John Prybylski, PhD, derived from the stability constant data base NIST 46. Missing data is not present in that data base.

Stability Constants for Currently Available Chelators Table:

Note that the stability constants favor the use of DTPA over the other chelating agents for all the exogenous heavy metals. We will attempt to find the missing data points from other sources.