Antihistamines as ancillary drugs for managing Flare in GDD (and other heavy metals)

Antihistamines for most GDD sufferers is a secondary drug of mild value. I have 3 approaches:

1. I currently most often use Atarax (hydroxyzine) 25 mg twice a day - has anti-anxiety properties so this is good for most GDD sufferers.

2. Alternative: 10 mg loratadine in morning, 10 mg montelucast at night. If the person is likely to also have Mast cell activation syndrome (MCAS), this approach may be better as these are two of the foundation drugs to treat MCAS. Montelucast has anti-leukotriene properties, which increases the broad coverage against inflammatory polypeptides.

3. Subject uses antihistamines they 'like and work for them' or 'affordable'. A large bottle of generic loratadine is quite ideal. Recommendation is one 10mg tab per day on the bottle. Through the course of taking steroids take 1 in morning and 1 at end of day.

Unlike steroids, there is not the intrinsic danger of staying long term on antihistamines. A GDD sufferer can take them just through the course of taking the steroid taper following DTPA chelation, or stay on them long term. Long term may be taking them consistently through the course of chelation therapies, from 5 to 10 to more chelations.

Richard Semelka, MD