Flare reactions Types of Flare Reactions and Their Management Following DTPA Chelation Introduction A Flare reaction is a temporary increase in the symptoms of heavy-metal toxicity occurring during or following chelation. The phenomenon has been most extensively observed in patients with Gadolinium Deposition Disease undergoing intravenous DTPA chelation. Similar reactions have also been observed in a smaller number of patients undergoing treatment for lead toxicity. A compar