Immune Dysregulation: A Large Seething, Bubbling Black Hole, with Multiple Entry Points, and Multiple Extensions that Arise as an Effect.

The concept of Immune System Dysregulation, causes and effects is presently one of my major focuses with GDD. GDD is often a late entry into the contributing bubbling black hole of Immune System Dysregulation.

The blog is an email I just sent to an individual. I intend that because of the importance of this subject, and that it is a developing field, many iterations of this will be subjects of present and future blogs and presentations of mine:

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There are no published series on the specific topic of GDD in combination with other immune dysregulation conditions. Almost everyone though have atleast simple combinations, such as mold toxicity, multiple chemical sensitivity syndrome and Mast Cell Activation Syndrome This has been a subject of considerable interest to me, and in recent blogs and presentations, such as on TikTok and you Tube, I have and will address it.

I consider immune dysregulation as one large amorphous black hole that many people have... maybe 30 million. The entry point may be from multiple different causes. GDD often is one of the last, and worst additions to that seething,bubbling black hole. Treating GDD often has a salutary effect on other conditions... I think the combination of removing Gd (and lead) and steroids and antihistamines. Sometimes the treatment of GDD is also directly the effective treatment for another, perhaps entry point condition (such as MCAS), but also additional treatment for other conditions should still be taken, and it may also be specific treatment for that other condition also benefits GDD. At present I am less sure of which other treatments, for example many Psoriasis treatments involve targeting/ suppressing one particular cytokine. I am very keen to learn if there is any one cytokine targeting drug that also seems to benefit GDD. I am not sure of it yet, so I presently do not advise taking one of these yet for GDD (eg: I do not yet recommend Humira, Cosentyx, Stelara, etc). It is conceivable that one of these DMARD drugs will benefit GDD - I hope so, but don't know yet which does.

So treatment of GDD should, if anything, benefit all other immune dysregulating conditions, and that has been my experience.

As I have the most experience I usually recommend people start chelation with me, and they can continue elsewhere, especially if things are going well and no complications encountered that require my greater expertize.

Richard Semelka, MD