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Gadolinium Storage Condition Individuals: What about Retained Gadolinium and Other Heavy Metals. Pro

GSC by definition are people who have received GBCAs but are not sick from them. However it is always the case they have retained Gd. Essentially the studies by Gibby and White regarding Gd retained in femoral head specimens following surgical resection for severe hip arthritis, presumably the patients all had GSC. All the current generation papers on Gd retained in the brain and being found throughout the body, presumably all in subjects with GSC. I personally have received upwards of 12 GBCA injections, and have GSC, but not GDD. I was shocked to see how much Gd, and other heavy metals, I have in me. DTPA also provoked significant amount of Gd and other metals out of me. All the urine samp

Chelation of Other Heavy Metals

DTPA has high stability constants for many metals. That doesn't necessarily mean that it will bind these metals in the in vivo environment, but at least it means that it is possible. The explanation is that many of these metals, for example Mercury (Hg) may exist in a number of species in vivo, and these will also have varying stability constants. Here are some log stability constants of DTPA for various metals (the higher the number, the stronger the metal binding): Metal Log K Gd 22.46 Co(II) 18.40 Hg 27.00 Pb 18.80 Zn 18.75 Ca 10.74 Thus, DTPA would be expected to be good for mercury (Hg) removal, but as mentioned above, it would also d

Can someone get GDD after just one GBCA injection, even if it is macrocyclic?

Most people do not get sick from GBCAs. PERIOD... Doesn't matter if they received 1 or 20, or if it is linear or macrocyclic. GDD is relatively rare - which is one of the reasonable explanations that radiologists and the manufacturers themselves generally want to deny its existence. Individuals who get GDD can get it after just one GBCA [linear or macrocyclic]; even after just 1 ml if it is a subcutaneous injection, MR arthrography, or other circumstances where the contrast is contained and not freely flowing through the vascular system; or it may arise after they have already received a few GBCAs and have been fine after the prior injections. It is rare that it starts completely out of the

Effectiveness of Treatment for GDD. Current status.

At the present time, I can reflect back on how we are doing with success rate with treatment for GDD, who does well, and where we are still in evolution. Traditionally with most diseases (eg: trauma, cancers, infections) the sooner you treat, the better the outcome. Very early on I recognized that this was not the case for patients with recent onset GDD and optimal treatment. The concept is: if Gd is the problem, use the best available method to get the Gd out. Simple concept, and the best available, FDA-approved chelator is DTPA. This is simple test-tube science: it has the highest stability constant for Gd uptake of all available FDA-approved chelators. Is it the absolute best chelator? A

Gd and Lead Chelation. Some Interesting Pointers.

The goal is not to get all the Gd out, that is impossible (at least 50% of Gd is in bones, and getting it out of bones is not that easy, even with agents that get Gd out of bones - DTPA). The goal is to get enough Gd out that you are about 80% better. A lot of the important part of treatment is dampening the immune response. FRAME is essential (not 100% essential if using Zn-DTPA alone- but close to 100%). What about Lead. Most practitioners are getting Lead out in individuals who are not sick from Lead - so the individuals have Lead storage condition and not Lead deposition disease. It is easy then: people with Lead storage condition do not Flare on removal of Lead, just like individuals wi

Similarities Between GDD and Poison Ivy

Poison ivy (also poison oak) contain on their leaves the chemical urushiol, and with skin contact the oily chemical adheres to skin, where it can pass through intact skin and is metabolized. The immune cells primarily involved to create the skin reaction are T-cells. Every year when I garden in the spring I seem to get poison ivy, even though I am careful, it also seems worse every year. It starts as a few painful serum-containing blisters on one or two digits, that are painful, burning and associated with redness, and I hope that will be it. No pustules. Then it progresses to involve much of both hands and now this year part of my face and torso, over a course of 4 days, and then generally

 
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