Chelation treatment alone in some GDD subjects will make them worse: Host response must be concurren
With experience with chelation and familiarity with patient status from around the world, chelation alone in many individuals may not be enough. In fact in some it seems to make them worse, although at present it is not clear if the worsening is limited to 1 year or so, or whether it is permanent.
In multiple blogs I have written about FRAME (which is an extended hypersensitivity protocol) and AMASE (which is concurrent treatment with autoimmune drugs), and maybe what I have not emphasized enough is:
Chelation treatment alone may make some GDD sufferers worse.
Which patient groups are most at risk of getting worse after chelation?
1. patients with GDD within 1 year of disease development.
2. patients who have received macrocyclic agents within 1 year in particular.
3. it is not clear if macrocyclic-agent-caused-GDD independent of duration may be worse after chelation alone.
It is clear to me that it is not just of value, but essential that host response be treated concurrently in these individuals.
I have described the major reason previously, which is that with recent onset disease the immune system is still on high alert and responds aggressively to remobilization of Gd. An additional factor that may apply to macrocyclics is that the work of Wermuth and Jiminez described that different GBCAs cause elevations of different cytokines. So it is possible that the type of cytokines elevated may play a factor in this, that macrocyclics may elevate cytokines that are more damaging than cytokines elevated by linear agents.
So, if you fit into the 3 categories above, the treatment you receive must include concurrent management of the host response. If it does not, untreated disease of GDD is very serious, but chelation-alone treatment may not only be not helpful, but apparently even worse. Although it should be noted that the duration of this prolonged severe Flare to chelation is not defined, it is possible it may diminish after 1 year. Also it is not clear how the prolonged severe Flare in some individuals compares to untreated disease, which is also progressive and severe, as it is impossible to have controlled comparisons. Accepting those two uncertainties, clearly prolonged severe Flare is very undesirable, and must be prevented/managed.
Stay tuned on the latest advancements: